学院： 理工学院                      

性别：女                    

职称：副研究员                    

学历：研究生

学位：博士

学习经历:

2007.1-2010.12香港中文大学，医学院，博士

2003.9-2006.6暨南大学，药学院，硕士

1999.9-2003.6   广东药科大学，药学院，学士

工作经历:

2016-至今暨南大学食品安全与营养研究院，副研究员

2013 -2015暨南大学，生物学博士后流动站博士后

2011-2012香港中文大学，生物医学学院，研究助理。

研究方向:

食品营养干预和功能性食品

主持科研项目

1.国家自然科学基金青年科学基金项目：含硒藻胆蛋白拮抗人胰淀素诱导的胰岛β细胞凋亡的作用机理（21201082），2013/01-2015/12，25万。

2.中国博士后科学基金：TrxR靶向性的新型有机硒化合物的抗肿瘤作用机理，2012/05-2014/04，5万。

3.广东省自然科学基金博士启动项目：含硒藻胆蛋白拮抗人胰淀素诱导的胰岛

β细胞凋亡的作用机理(S2012040006919)，2012/10-2014/09，3万。

4.暨南大学引进人才科研配套经费：有机硒对糖尿病引起肿瘤耐药的营养干预机制，201609/05-2019/09，20万。

5. 广东嘉应制药股份有限公司横向课题：抗肿瘤纳米药物的开发，2015/01-2018/12，40万。

代表性论文

1、Wen Liu#, Xiaoling Li # (共同第一作者), Yum-Shing Wong, Wenjie Zheng*, Yibo Zhang, Wenqiang Cao, Chen Tianfeng*. Selenium nanoparticles as a carrier of 5-Fluorouracil to achieve anticancer synergism. ACS Nano, 2012, 6 (8), 6578–6591.(IF=12.062，1区)

2、Xiaoling Li#, Lijuan Ma#, Wenjie Zheng, Tianfeng Chen*. Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis. Biomaterials, 2014, 35, 8596-8604. (IF=8.312，1区)

3、Li Y#, Li Xiaoling # (共同第一作者), Wong YS, Chen Tianfeng*, Zhang H, Liu C, Zheng W*. The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials, 2011, 32, 9068-9076.(IF=8.312，1区)

4、Yifan Wang, Wenying Li, Yahui Yang, Qinsong Zeng, Ka-Hing Wong, Xiaoling Li* and Tianfeng Chen*. An integrin-targeting nanosystem as a carrier of the selenadiazole derivative to induce ROS-mediated apoptosis in bladder cancer cells, from rational design to action mechanisms. J. Mater. Chem. B, 2015, 3, 9374-9382.(IF=6.627，1区)

5、Yinghua Li, Xiaoling Li*, Wen-Jie Zheng, Cundong Fan, Yibo Zhang and Tianfeng Chen*. Functionalized selenium nanoparticles with nephroprotective activity, the important roles of ROS-mediated signaling pathways.J. Mater. Chem. B, 2013, 1 (46), 6365 – 6372. (Back cover).(IF=6.627，1区)

6、Wei Huang, Hualian Wu, Xiaoling Li*, Tianfeng Chen*. Facile one-pot synthesis of tellurium nanorods as antioxidant and anticancer agents. Chemistry-An Asian Journal, 2016, 11(16), 2218–2334.(IF=4.587)

7、Shulin Deng, Delong Zeng, Yi Luo, Jianfu Zhao, Xiaoling Li*, Zhennan Zhao, Tianfeng Chen*. Enhancement of Cell Uptake and Antitumor Activity of Selenadiazole Derivatives through Interaction and Delivery by Serum Albumin. RSC Advances. 2017, 7, 16721-16729.(IF=3.289)

8、Jianfu Zhao, Delong Zeng,  Yuedan Liua,  Yi Luo,  Shengbin Ji,  Xiaoling Li* and Tianfeng Chen*. Selenadiazole derivatives antagonize hyperglycemia-induced drug resistance in breast cancer cells by activation of AMPK pathways. Metallomics. 2017 Apr 4. doi: 10.1039/c7mt00001d. (IF=3.540)

9、Xiaoyan Fu, Yahui Yang, Xiaoling Li*, Haoqiang Lai, Yanyu Huang, Lizhen He, Wenjie Zheng, Chen Tianfeng*.RGD peptide-conjugated selenium nanoparticles: antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12, 1627–1639. (IF=5.671)

10. Xiao-Ling Li, Tianfeng Chen, Yum-Shing Wong, Gang Xu*, Rong-Rong Fan, 

Hai-Lu Zhao, Juliana C.N. Chan*. Involvement of mitochondrial dysfunction in

 human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta

 cells: an effect attenuated by phycocyanin. The International Journal of

 Biochemistry & Cell Biology. 2011, 43, 525-534.(IF=4.634)

11. Li Xiaoling, Wong YS, Xu G, Chan JC*. Selenium-enriched Spirulina protects 

INS-1E pancreatic beta cells from human islet amyloid polypeptide-induced 

apoptosis through suppression of ROS-mediated mitochondrial dysfunction and 

PI3/AKT pathway. Eur J Nutr. 2014 Aug 12. (IF=3.840)

12、Xiao-Ling Li, Gang Xu, Chen Tianfeng, Yum-Shing Wong, Hai-Lu Zhao, Rong-

Rong Fan, Xue-Mei Gu, Peter C.Y. Tong, Juliana C.N. Chan. Phycocyanin

Protects INS-1E pancreatic beta cells against human islet amyloid

polypeptide-induced apoptosis through attenuating oxidative stress and 

modulating JNK and p38 mitogen-activated protein kinase pathways. The 

International Journal of Biochemistry & Cell Biology. 2009, 41,

1526-1535.(IF=4.634)

13.  Lijuan Ma#, Xiaoling Li# (共同第一作者),Yi Wang, Wenjie Zheng and 

Tianfeng Chen*. Cu(II) inhibits hIAPP fibrillation and promotes hIAPP-induced

beta cell apoptosis through induction of ROS-mediated mitochondrial 

dysfunction. Journal of Inorganic Biochemistry, 2014, 140, 143–152. 

(IF=3.197)

14.  Qiang Xie#, Shenggui Liu#, Xiaoling Li# (共同第一作者), Qiong Wu, Zuandi

Luo, Xiaoyan Fu, Wenqiang Cao, Guoqiang Lan, Dan Li,* Wenjie Zheng, 

Tianfeng Chen*. Dinuclear Zinc(II) Complexes Containing 

(Benzimidazo1-2-yl)benzene That Overcome Drug Resistance in Hepatocellular 

Carcinoma Cells through Induction of Mitochondria Fragmentation. Dalton 

Transactions. 2014, 43 (19), 6973 – 6976.(IF=3.838)

15.  Fang Yang, Ka-Hing Wong, Yufeng Yang, Xiaoling Li*, Jie Jiang, Wenjie 

Zheng*, Hualian Wu, Tianfeng Chen. Purification and in vitro antioxidant 

activities of tellurium-containing phycobiliproteins from tellurium-enriched

 Spirulina platensis. Drug Design, Development and Therapy, 2014, 8, 

1789-1800.(IF=3.026)

16.  Yuedan Liu, Yi Luo, Xiaoling Li*, Wenjie Zheng, Tianfeng Chen*. Rational

  design of selenadiazole derivatives to antagonize hyperglycemia-induced drug 

  resistance in cancer cells. Chemistry-An Asian Journal. 2015. 10, 3, 642–652. 

  (Back Cover). (IF=3.935)

17. Lijuan Ma, Yuanting Fu, Lianling Yu, Xiaoling Li*, Wenjie Zheng, Tianfeng 

   Chen*. Ruthenium complexes as inhibitors of human islet amyloid polypeptide

   aggregation, an effect that prevents beta cell apoptosis. RSC Advances. 2015, 5,

   17405-17412. (IF=3.708)

18. Yuan-Wei Liang,Junsheng Zheng,Xiaoling Li*,Wenjie Zheng, Tianfeng Chen*. 

   Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance 

   the radiosensitivity of cancer cells. European Journal of Medicinal Chemistry. 

   2015，84(30), pp 335-342. (IF=3.432)

19.  Su, Jianyu*; Lai, Haoqiang; Chen, Jianping; Li, Lin; Wong, Yum-Shing; Chen, 

Tianfeng; Li, Xiaoling*. Natural Borneol, a Monoterpenoid Compound, 

Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular 

Carcinoma Cells by Enhancement of Cellular Uptake and Activation of

 ROS-Mediated DNA Damage. PLos One, 8(6), 2013/5/20.  (IF=3.534)