学习经历:

2000.9-2006.3   美国纽约市立大学研究生院分子微生物学专业哲学博士

1998.10-2000.9  新加坡南洋理工大学微生物学专业理学硕士

1991.9-1995.6   南开大学微生物学专业理学学士

工作经历:

2016-至今暨南大学食品安全与营养研究院特聘教授

2010 –至今美国纽约大学医学院资深研究科学家助理教授

2008-2009  美国纽约大学医学院博士后研究员

2006-2008  美国得克萨斯农业及机械工程大学博士后研究员

1995-1998  广东省微生物研究所工程师

研究方向:

1.幽门螺旋杆菌导致人体上消化道系统癌症的分子机制;

2.幽门螺杆菌的持续感染对人体免疫系统和消化道微生物菌群的调控学习经历:

承担及参与项目

1.项目实验基金RTI：6万美元，首席研究者。

2.美国比尔盖茨科研基金：40万美元，合作研究者。

3.美国国家基金NIH：100万美元，合作研究者。

4.强生制药研发：80万美元，合作研究者。

代表性论文

1、Kienesberger S, Cox LM, Livanos A, Zhang XS, et al. Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses. Cell Report. 2016 Feb 3. pii: S2211-1247. PMID:26074426, PMCID: PMC4490391 (IF=8.36)

2、Beaulaurier J, Zhang XS, Zhu S, Sebra R, Rosenbluh C, et al. Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes. Nature communications. 2015; 6:7438. PMID:26074426, PMCID: PMC4490391 (IF=11.47)

3、Zhang XS*, Tegtmeyer N, Traube L, Jindal S, Perez-Perez G, et al. A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions. PLoS pathogens. 2015; 11(2):e1004621. PMID: 25646814, PMCID: PMC4412286 (IF=9.13) (*corresponding author)

4、Maldonado-Contreras A, Mane SP, Zhang XS, Pericchi L, Alarcón T, et al. Phylogeographic evidence of cognate recognition site patterns and transformation efficiency differences in H. pylori: theory of strain dominance. BMC microbiology. 2013; 13:211. PMID: 24050390, PMCID: PMC3849833 (IF=3.10)

5、Zhang XS*, Blaser MJ. DprB facilitates inter- and intragenomic recombination in Helicobacter pylori. Journal of Bacteriology. 2012; 194(15):3891-903. PMID: 22609923, PMCID: PMC3416544 (IF=3.94) (*corresponding author)

6、Zhang XS*, Blaser MJ. Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases. Journal of Bacteriology. 2012; 194(13):3407-16. PMID: 22522893, PMCID: PMC3434758 (IF=3.94) (*corresponding author)

7、Kim Y, Wang X, Zhang XS, Grigoriu S, Page R, et al. Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental Microbiology. 2010; 12(5):1105-21. NIHMSID: NIHMS565596 PMID: 20105222, PMCID: PMC3980499 (IF=5.34)

8、Lin EA, Zhang XS, Levine SM, Gill SR, Falush D, et al. Natural transformation of Helicobacter pylori involves the integration of short DNA fragments interrupted by gaps of variable size. PLoS pathogens. 2009; 5(3):e1000337. PMID: 19282979, PMCID: PMC2650093 (IF=9.13)

9、Kim Y, Wang X, Ma Q, Zhang XS, Wood TK. Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. Journal of Bacteriology. 2009; 191(4):1258-67. PMID: 19060153, PMCID:PMC2632003 (IF=3.94)

10、Lee J, Zhang XS, Hegde M, Bentley WE, Jayaraman A, et al. Indole cell signaling occurs primarily at low temperatures in Escherichia coli. The ISME journal. 2008; 2(10):1007-23. PMID: 18528414 (IF=9.30)

11.  García-Contreras R, Zhang XS, Kim Y, Wood TK. Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes. PloS one. 2008; (6):e2394. PMID: 18545668, PMCID: PMC2408971 (IF=4.09)

12. Zhang XS, García-Contreras R, Wood TK. Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). The ISME journal. 2008; 2(6):615-31. PMID: 18309357 (IF=9.30)

13. Lee J, Page R, García-Contreras R, Palermino JM, Zhang XS, et al. Structure and function of the Escherichia coli protein YmgB: a protein critical for biofilm formation and acid-resistance. Journal of Molecular Biology. 2007; 373(1):11-26. NIHMSID: NIHMS31473 PMID: 17765265, PMCID: PMC2185545 (IF=4.33)

14. Zhang XS, García-Contreras R, Wood TK. YcfR (BhsA) influences Escherichia coli biofilm formation through stress response and surface hydrophobicity. Journal of Bacteriology. 2007; 189(8):3051-62. PMID: 17293424, PMCID: PMC1855844 (IF=3.94)

15. Zhang XS, Cheng HP. Identification of Sinorhizobium meliloti early symbiotic genes by use of a positive functional screen. Applied and Environmental Microbiology. 2006; 72(4):2738-48. PMID: 16597978, PMCID: PMC1449070 (IF=3.95)